Amitriptyline (Elavil)

Updated February 17, 2014
Author: Paula McKinley RN

Description: Amitriptyline as an adjunct to Pain Management


Amitriptyline (Elavil) as an Adjunct to Pain Management

  • A Tricyclic Antidepressant; Noreipinephrine & Epinephrine reuptake inhibitor
  • Indications:
    • Depression
    • Neuropathic Pain
    • PM dose for sleep
  • Dosing:
    • Usually given at bedtime.
      • Start with 25 mg PO (10 mg for elderly), increase q3-5 days as tolerated to a max of 75-150 mg hs.
    • May take 1-3 weeks to note beneficial effect.
  • Availability:
    • Tablets 10mg, 25mg, 50mg, 75mg, 100mg
  • Side effects:
    • Dry mouth, blurred vision, urinary retention constipation, reflux
    • weakness, lethargy fatigue, paradoxical excitement
  • Precautions:
    • BPH, closed angle glaucoma, seizure disorder