- Indigo Carmine is a sterile dye for injectable use in surgery. Originally employed as a kidney function test, the chief application of Indigo Carmine at present is localizing ureteral orifices during cystoscopy and ureteral catheterization
- Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body.
- Elimination of the dye begins soon after injection, appearing in the urine within 10 minutes in average cases.
- The biological half-life is 4 to 5 minutes following intravenous injection.
- Larger quantities are necessary when intramuscular injection is employed. Appearance time and elimination are delayed following intramuscular injection.
- HOW SUPPLIED:
- Indigo Carmine Injection
NDC 0517-0375-10 5 mL ampules packaged in boxes of 10
FOR INTRAVENOUS OR INTRAMUSCULAR USE
- Sufficient Indigo Carmine is contained in each 5 mL ampule to permit accurate withdrawal and administration of the full dose. It gives a deep blue solution when dissolved in water.
Clinical Uses & Dosing for Indigo Carmine
- Urologic & Gyn Surgery
- The chief application of Indigo Carmine is localizing ureteral orifices during cystoscopy and ureteral catheterization.
- Intravenously injected Indigo Carmine is readily released into the urine and thus can be used to test the urinary tract for leaks or fistulas
- DOSAGE AND ADMINISTRATION Indigo Carmine solution is injected either by the intravenous or intramuscular route, and its appearance at the ureteral orifices is watched with the cystoscope in place.
- The intravenous method is preferred because a 5 mL injection is sufficient.
- A lesser dosage in infants, children and underweight patients will prevent skin coloration.
- Since precipitation of indigotindisulfonate sodium may occur, Indigo Carmine Solution must not be diluted prior to injection or injected with infusion assemblies which were used with other solutions.
Caveats for Indigo Carmine
- Effects on Pulse Oximetry: Transient, marked decrease in SpO2 lasting up to several minutes. If concern about hypoxia exists do a ABG.
- CONTRAINDICATIONS Indigo Carmine is contraindicated in patients who have previously experienced an adverse reaction following its use.
- ADVERSE REACTIONS & WARNINGS
- An occasional idiosyncratic drug reaction may occur.
- A mild pressor effect may be encountered in some patients.
- Pregnancy Category C:
Animal Reproduction studies have not been conducted with indigotindisulfonate sodium injection. It is also not known whether indigotindisulfonate sodium injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Indigotindisulfonate sodium injection should be given to a pregnant woman only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Indigo Carmine is administered to a nursing woman.
- OVERDOSAGE There are no data available describing the signs, symptoms or laboratory findings accompanying overdosage.
No discernible symptoms of toxicity have been observed in mice with an intravenous dose of 200 mg/kg. After intravenous administration the LD50was established at 300 mg/kg in mice.