Gabapentin (Neurontin®)

Updated April 15, 2014
Author: Paula McKinley RN

Description: Gabapentin as an adjunct to Pain Management

Gabapentin as an Adjunct to Pain Management

  • Description: Anticonvulsant, adjunct antineuralgic
  • Indications:
    • Commonly used neuropathic pain medication, marketed as an anticonvulsant
    • Prevents allodynia and hyperalgesia
    • Useful in post-herpetic neuralgia
  • Dosing:
    • Start at 300mg PO hs or lower (100 mg) in elderly.
    • Gradual escalation every 3-5 days to range of 1200mg TID as tolerated.
    • Beneficial effects expected in 1-3 weeks of therapy.
    • Max dose 3600 mg/day
  • Availability:
    • Tablets, Capsules: 100mg, 300mg, 400mg, 600mg, 800mg
    • Oral solution: 250mg/5 ml
  • Side Effects:
    • Usually well tolerated, side effects often self-limiting
    • Somnolence, dizziness, or fatigue, ataxia (CNS), mild dyspepsia (GI), diplopia
  • Precautions:
    • Do not discontinue abruptly (may increase likelihood of seizure)
    • Decrease dose with renal compromise