Pyridostigmine (Mestinon®)

Updated May 9, 2015
Author: VerLee; Source: Stoeling 1999, Miller 2013

Description: Clinical Tips for medical Pyridostigmine, especially as related to the practice of anesthesia


Mechanism of Action


Pharmacokinetics

Anticholinesterases

Clinical Uses & Dosing for Pyridostigmine

Typical Dosing of Pyridostigmine with Anticholinergics
Degree of Blockade (Train of Four) Pyridostigmine Atropine Glycopyrrolate
1/4 TOF Present 0.4 mg/kg 40 mcg/kg 20 mcg/kg
2-3/4 TOF Present 0.2 mg/kg 20 mcg/kg 10 mcg/kg
4/4 TOF Present 0.1 mg/kg 10 mcg/kg 5 mcg/kg

Caveats for Pyridostigmine