Glycopyrrolate (Robinul®)

Updated December 20, 2013
Author: VerLee

Description: Clinical Tips for medical glycopyrrolate, especially as related to the practice of anesthesia

See also Atropine and Scopolamine

Mechanism of Action

Glycopyrrolate combines reversibly (competitve antagonism) with muscarinic cholinergic receptors, and thus prevents access of the neurotransmitter acetylcholine to these sites. It is termed an anticholinergic.

Other drugs in the class include atropine and scopolamine, and Ipratropium. Anticholinergic drugs do not prevent the liberation of acetylcholine, nor do they react wih acetylcholine.


Pharmacokinetics

IV Administration: onset of action 2-3 minutes; duration of action 30-60 minutes.

Glycopyrrolate, in contrast to atropine and scopolamine, is a non-lipid soluble quaternary amine, and hence does NOT cross the blood-brain barrier. It has minimal CNS effects such as sedation or delerium, and thus makes it a wise choice for use in the elderly, and when treating peripheral effects of physostigmine.

from Stoelting


Clinical Uses & Dosing for Glycopyrrolate