Neostigmine (Prostigmin®,Bloxiverz®)

Updated March 6, 2014
Author: VerLee; Source: Stoeling 1999, R.Miller 2013 , A. Miller 2014

Description: Clinical Tips for medical neostigmine, especially as related to the practice of anesthesia


Mechanism of Action


Pharmacokinetics

Anticholinesterases

Clinical Uses & Dosing for Neostigmine

Typical Dosing of Neostigmine with Anticholinergics
Degree of Blockade (Train of Four) Neostigmine Atropine Glycopyrrolate
1/4 TOF Present 60 mcg/kg 30 mcg/kg 15 mcg/kg
2-3/4 TOF Present 40 mcg/kg 20 mcg/kg 10 mcg/kg
4/4 TOF Present 30 mcg/kg 15 mcg/kg 7 mcg/kg

Caveats for Neostigmine