Updated December 20, 2013
Author: VerLee, source Miller, Stoelting

Description: Clinical Tips for medical scopolamine, especially as related to the practice of anesthesia

see also atropine and glycopyrrolate

Mechanism of Action

Scopolamine combines reversibly (competitve antagonism) with muscarinic cholinergic receptors and thus prevents access of the neurotransmitter acetylcholine to these site. It is thus termed an anticholinergic.

Other drugs in the class include glycopyrrolate and atropine, and Ipratropium. Anticholinergic drugs do not prevent the liberation of acetylcholine, nor do they react wih acetylcholine.


IV Administration: onset of action about 2-3 minutes.

Scopolamine, like atropine, is a lipid soluble tertiary amine, and thus easily crosses the blood-brain barrier, causing CNS effects of sedation and delerium, esp. in the elderly (See Central Anticholinergic Syndrome).

from Stoelting

Clinical Uses & Dosing for Scopolamine